Cathepsin S, Human Spleen

Product Number 16-18-030118

This product is NOT recombinant.

Packaged 25 ug per vial

MW 24,000

Lyophilized from 100 mM Na Acetate, pH 5.5, 1 mM EDTA.

Storage: -80 Degrees C

Like Cathepsins B, H, and L, Cathepsin S belongs to the group of lysosomal cysteine proteases. Cathepsin S is found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides.

Activity: Cathepsin S activity detected using Z-Val-Val-Arg-AMC (Bachem: I-1540)

Ref.: Shi, G.P., et al. 1994. J. Biol. Chem. 15, 11530. Lemere, C.A., et al. 1995. Am J. Pathol. 146(4): 848. Munger, J. S., et al. 1995. Biochem. J. 311: 299.

Prepared from tissue shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.


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