Myeloperoxidase Enzyme Immunoassay Kit

1 Plate
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USE - Measure human MPO in a variety of matrices
SAMPLE -Serum, Platelet-Poor Heparin Plasma, Saliva, Urine or Tissue Culture Media
SAMPLES / KIT - 40 in duplicate
SENSITIVITY - 0.068 ng/mL
STABILITY - liquid reagents stable at 4°C

Myeloperoxidase (MPO) is a tetrameric heme-containing protein abundantly produced in neutrophil granulocytes where it plays an important anti-microbial role. During degranulation MPO is released into the extracellular space. There, as part of the neutrophils “respiratory burst”, it produces hypochlorous acid from hydrogen peroxide and Cl–. MPO also uses hydrogen peroxide to oxidize tyrosine to the tyrosyl radical. Both hypochlorous acid and tyrosyl are cytotoxic and when present can kill bacteria and other pathogens. Hereditary deficiency of myeloperoxidase predisposes individuals to immune deficiency.

Studies have shown an association between elevated MPO levels and coronary artery disease, and in 2003 it was suggested that MPO may serve as a sensitive predictor of myocardial infarction in patients complaining of chest pain. Since that time the clinical utility of MPO testing in cardiac patients has been solidly established in the literature with well over 100 papers published. In 2010 this clinical application was further refined by additional studies which determined that measuring both MPO and C-reactive protein (CRP) provided more accurate prediction of mortality risk than measuring just CRP alone.

Zhang et al. (2001) Association between myeloperoxidase levels and risk of coronary artery disease; JAMA, 286 2135
Brennan et al. (2003) Prognostic value of myeloperoxidase in patients with chest pain; New Engl. J. Med., 349 1595
Heslop et al. (2010) Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography; J. Am. Coll. Of Cardiol. 55 1102

Athens Research and Technology (ART) has partnered with Arbor Assays to offer the best MPO EIA kit available. The founders and top scientists from Arbor Assays have been researching and developing high quality assay kits since 1982, so ART utilized our 30 years of experience advancing and perfecting techniques in protein purification to isolate a superior quality antigen which the Arbor Assays team then developed into a top of the line EIA featuring a unique antibody pairing along with careful optimization and their trademark exceptional quality control. The Athens Research and Technology/Arbor Assays human MPO EIA kit has been validated for serum, platelet-poor heparin plasma, saliva, urine and tissue culture media with results in just 2.5 hours and a sensitivity of 0.68 ng/ml. The kit is available for purchase from either company (Arbor Assays cat.# K060-H1, Athens Research and Technology cat.# K060-H1).

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Athens Research and Technology Reagents:
Myeloperoxidase, Human Neutrophils – 16-14-130000
High Density Lipoprotein (HDL), Human, Plasma – 12-16-080412
Ceruloplasmin, Human Plasma – 16-16-030518
Superoxide Dismutase (SOD), Human Erythrocytes – 16-05-191504
Elastase, Human Neutrophils – 16-14-051200
Eosinophil Peroxidase (EPO), Human Eosinophils – 16-15-160518
Lactoferrin, Human Milk – 16-13-120103