Thrombospondin, Human Platelet

25 ug
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Special Note: This product is aliquoted in siliconized tubes and must be handled using siliconized containers and pipette tips.

MW: 420,000 Da
Extinction Coefficient: 0.91

Lyophilized from 20 mM Tris-HCl, pH 8.0, with 600 mM NaCl, 2 mM CaCl2, and 20% sucrose
Reconstitution: After centrifugation, we suggest addition of de-ionized H2O to the original volume, followed by gentle mixing to ensure adequate homogenization. This product may precipitate at concentrations greater than 0.50 mg/ml.

A cellular adhesion protein. Thrombospondin is a component of the coagulation mechanism and is believed to have potential as a marker for platelet activation and renal failure.

Synonym: THBS1, THBS, TSP1, TSP, Thrombospondin-1

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Prepared from platelets shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citations:
Stein, Jeffrey J., Chinenye Iwuchukwu, Kristopher G. Maier, and Vivian Gahtan. "Thrombospondin-1-induced smooth muscle cell chemotaxis and proliferation are dependent on transforming growth factor-β2 and hyaluronic acid synthase. Molecular and cellular biochemistry(2013): 1-6.

Haredy, Ahmad M., Akitoshi Nishizawa, Kohsuke Honda, Tomoshi Ohya, Hisao Ohtake, and Takeshi Omasa. "Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression. Cytotechnology(2013): 1-10.

Green, David E., Bum-Yong Kang, Tamara C. Murphy, and C. Micheal Hart. "Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation. Pulmonary circulation 2, no. 4 (2012): 483

Métayer LE, Vilalta A, Burke GAA, Brown GC.
Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis.
Oncotarget, Advance Publications 2017.

Neubauer EF, et al. A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis. Elife. 2017 May 8;6. pii: e24494. doi: 10.7554/eLife.24494.

Arias DL, et al. HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction. Cardiovasc Res. 2016 Jan 1;109(1):115-30. doi: 10.1093/cvr/cvv243. Epub 2015 Oct 26.

Nevitt C, McKenzie G, Christian K, Austin J, Hencke S, Hoying J, LeBlanc A. Physiological levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from aged rats.
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1842-50. doi: 10.1152/ajpheart.00086.2016. Epub 2016 May 3.

Murmann T, et al. Staurosporine and Extracellular Matrix Proteins Mediate the Conversion of Small Cell Lung Carcinoma Cells into a Neuron-Like Phenotype. PLoS One. 2014 Feb 28;9(2):e86910. doi: 10.1371/journal.pone.0086910. eCollection 2014.