Inter Alpha Inhibitor Proteins (IaIp), Human Plasma

25 ug
100 ug
1 mg
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MW: 225,000 and 125,000 Da

Frozen in 1 x PBS

Storage: <= -70°C

Inter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of the proteins is a function of bikunin, the common light chain of the IAIP.

In acute inflammation, the lal acts as a negative acute-phase protein, whereas the Pal acts as a positive acute-phase protein. IaIp are being considered as biomarkers and biotherapies for metastatic disease, septic shock and complement system disorders.

Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

Purity: >=90% by SDS PAGE

Immunoblotting: Immunoreactive with anti-Bikunin

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents produced in the U.S. and are not to be administered to humans or used for any drug purpose.

For research use or for use in further manufacturing.