Myeloperoxidase, Human Neutrophil

100 ug
1 mg
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MW: 130,000-150,000 Da
Extinction Coefficient: 1.45

Lyophilized from 50 mM Na acetate, pH 6.0 with 100 mM NaCl

This heme protein catalyzes oxidations by hydrogen peroxide, including MPO- chloride mediated killing of microbes and tumor cells, inactivation of hemotactic factors, crosslinking of proteins and inclination of proteins.

Activity: 180-220 units per mg protein after lyophilization. One unit is defined as the amount of enzyme that decomposes one umole of hydrogen peroxide per minute at 25oC , pH 6.0. Reaction mixture contains 30mM sodium phosphate, pH 6.1, 30mM guaiacol, and 0.0012% (0.35mM) hydrogen peroxide.

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti- HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citations:
Yogalingam G, et al. Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells. J Biol Chem. 2017 Mar 10;292(10):4255-4265. doi: 10.1074/jbc.M116.739441. Epub 2017 Jan 23.

Chiu CF, et al. Nanoemitters and innate immunity: the role of surfactants and bio-coronas in Myeloperoxidase-catalyzed oxidation of pristine single-walled carbon nanotubes. Nanoscale. 2017 May 11;9(18):5948-5956. doi: 10.1039/c6nr07706d.

Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, Yamaguchi Y. Roles of myeloperoxidase and GAPDH in interferon-gamma production of GM-CSF-dependent macrophages.
Heliyon. 2016 Feb 23;2(2):e00080. doi: 10.1016/j.heliyon.2016.e00080. eCollection 2016 Feb.

Chavali B, et al. ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments. Appl Magn Reson. 2015;46(8):853-873. Epub 2015 May 19.

Yamaguchi R, et al. Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps. Blood Cells Mol Dis. 2015 Aug;55(2):127-33. doi: 10.1016/j.bcmd.2015.05.012. Epub 2015 May 31.

Zhao Y, et al. Nano-Gold Corking and Enzymatic Uncorking of Carbon Nanotube Cups. J Am Chem Soc. 2015 Jan 21;137(2):675-84. doi: 10.1021/ja511843w. Epub 2015 Jan 7.

Kurapati R, et al. Dispersibility-Dependent Biodegradation of Graphene Oxide by Myeloperoxidase. Small. 2015 Aug 26;11(32):3985-94. doi: 10.1002/smll.201500038. Epub 2015 May 8.