Proteinase 3 (PR3), Human Neutrophil

25 ug
100 ug
1 mg
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MW: 29,000
Extinction Coefficient: 1.0

Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl

Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation.

Storage: <= -70°C

Purity: >= 95% by SDS-PAGE.

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citations:
Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, et al.
Modulation of γδ T cell activation by neutrophil elastase.
Immunology. 2017 Sep 9. doi: 10.1111/imm.12835. [Epub ahead of print]

Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, et al. Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles.
J Biol Chem. 2016 May 13;291(20):10476-89. doi: 10.1074/jbc.M115.698639. Epub 2016 Mar 9.

Schreiber A, Eulenberg-Gustavus C, Bergmann A, Jerke U, Kettritz R.
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.
J Leukoc Biol. 2016 Dec;100(6):1443-1452. Epub 2016 Jun 30.

Barauskas O, et al. Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.
Biochim Biophys Acta. 2014 Dec;1840(12):3292-8. doi: 10.1016/j.bbagen.2014.08.002. Epub 2014 Aug 17.