C1 Esterase Inhibitor, Human Plasma

1 mg
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MW: 100,000
Extinction Coefficient: 0.4

Frozen in 20 mM potassium phosphate, pH 7.0, with 250 mM potassium chloride

Storage: <= -70°C

Bulk Qty Available.

A single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, Factors XIa. XIIa, and plasmin. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the C1EI is non-functional.

Purity: >=95% by SDS-PAGE

Synonym: Complement C1 esterase inhibitor, Esterase inhibitor C-1

Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:

Salvesen, G.S et al. 1985. J. Biol. Chem. 260, 2432.

Lee, Kyoung Geun, Haneulnari Lee, Jeong Mi Ha, Young Kyung Lee, Hee Jung Kang, Chung‐Gyu Park, and Sang Joon Kim. "Increased human tumor necrosis factor‐α levels induce procoagulant change in porcine endothelial cells in vitro."Xenotransplantation 19, no. 3 (2012): 186-195

Kang, Hee Jung, Haneulnari Lee, Jeong-mi Ha, Jae-il Lee, Jun-Seop Shin, Ki-Yong Kim, Ji Yoon Park et al. "The Role of the Alternative Complement Pathway in Early Graft Loss After Intraportal Porcine Islet Xenotransplantation." Transplantation (2014)

Kenninston JA, et al. Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody. J Biol Chem. 2014 Aug 22;289(34):23596-608. doi: 10.1074/jbc.M114.569061. Epub 2014 Jun 26.

Zamolodchikov D, Renner T, Strickland S.
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
J Thromb Haemost. 2016 May;14(5):995-1007. doi: 10.1111/jth.13209. Epub
2016 Feb 29.