Complement C3c, Human Plasma

1 mg
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MW: 138,000
Extinction Coefficient: 1.03

Frozen in PBS, pH 7.4

Storage: ≤ -70°C - Avoid Freeze/Thaw cycles

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Complement C3 (C3) is the most abundant component of the complement system, with levels in human plasma of ~1.2-1.5 mg/ml. It is central to the activation of both the classical and alternative complement pathways, both of which lead to the proteolytic processing of C3 to C3a and C3b. C3 exists as a heterodimer with molecular masses of 115 kDa and 75 kDa, although it is readily processed to create C3a, C3b or C3c depending on the processed state.

Purity: ≥95% by SDS-PAGE.
Reacts to C3 antisera on Western Blot
Negative against C4 antisera on Western Blot

Not biologically active.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Ref: Tack BF and JW Prahl. 1976. Biochemistry. 15:4513, Tack BF et al. 1981. Methods Enzymol. 80:64, Janatova, J. 1988. Methods Enzymol. 162:579.