Haptoglobin, Low Endotoxin Level, Human Plasma

PRODUCT NUMBER:

Buy Purified Native Human Haptoglobin direct from manufacturer.

MW: Hp 1-1: 86,000; Hp 2-1: 200,000; Hp 2-2: 400,000
Extinction Coefficient: 1.20

Salt-free lyophilized solid.

Storage: <= -20°C

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.

Purity: >=95% by SDS-PAGE; by polymorphic form
Endotoxin Level: <2.0 EU/mg by fluorogenic assay, Lonza, 50-658U

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Ref:
Smithies, O et al. 1955. Biochem. J. 61, 629.
Sadrzadeh, S.M.H. et al. 2004. Clin. Chem. 50, 1095.