Immunoglobulin G3 (IgG3), Normal Human Plasma

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MW: 170,000 Da
Extinction Coefficient: 1.36

Liquid in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.

Like IgG1, IgG3 activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection.

Storage: 2-8°C

Purity: >=95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citations:
IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies. Bhat NM, Kshirsagar MA, Bieber MM, and Teng NNH. Immunol Invest. 2015;44(4):400-10. doi: 10.3109/08820139.2015.1015682.

Plomp R, et al. Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3). Mol Cell Proteomics. 2015 May;14(5):1373-84. doi: 10.1074/mcp.M114.047381. Epub 2015 Mar 10.