Immunoglobulin M (IgM), Human Myeloma Plasma

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MW: 970,000 Da
Extinction Coefficient: 1.18

Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3.

IgM is found in normal plasma at a concentration of 1.2 to 4.0 mg/ml. It is the first immunoglobulin produced during the immune response, the first antibody in neonates, and is involved in pathogenesis of autoimmune diseases. A diminished level of IgM is associated with Wiskott-Aldrich syndrome.

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Prepared from myeloma plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Laurent L, et al. IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies.
Ann Rheum Dis. 2015 Jul;74(7):1425-31. doi: 10.1136/annrheumdis-2013-204543. Epub 2014 Mar 11.