Vitronectin, Human Plasma

100 ug
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MW: 65,000 and 75,000 Da
Extinction Coefficient: 1.38

Lyophilized from 10 mM sodium phosphate, pH 7.7

Vitronectin and plasminogen activator inhibitor type 1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration. Plasminogen activator inhibitor type 1, a serine proteinase, through its binding to the plasma protein vitronectin, influences processes that are key regulators of hemostatic process, for example, thrombosis and wound healing. In addition the vitronectin and plasminogen activator inhibitor type 1 complex regulates binding of blood platelets and cells to extracellular substrata in events like tumor metastasis. The plasma concentration of vitronectin is 200 to 400 μg/ml.

Storage: <= -20°C

Purity: approximately 95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Wihadmadyatami H, Röder L, Berghöfer H, Bein G, Heidinger K, Sachs UJ, Santoso S. Immunisation against IIb3 and v3 in a type 1 variant of Glanzmann's thrombasthenia caused by a missense mutation Gly540Asp on 3. Thromb Haemost. 2016 Aug 1;116(2):262-71. doi: 10.1160/TH15-12-0982. Epub 2016 Apr 21.