Immunoglobulin A (IgA), Human Plasma

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1 mg
$55.00
10 mg
$370.00
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PRODUCT NUMBER:

16-16-090701

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MW 160,000
Extinction Coefficient = 1.32

Frozen in 100 mM Tris-HCl, pH 8.0, with 100 mM NaCl and 0.05% NaN3.


IgA is the most abundant immunoglobulin in body fluids and the second most abundant immunoglobulin in plasma, found at a concentration of 0.4 to 2.2 mg/ml. It plays a very important role in the first specific defense against natural infection. Secretory IgA differs from serum IgA in that it contains two additional peptides: the secretory component and the J chain.


Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.


Product Citation:
Bidgood SR, et al. Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8. doi: 10.1073/pnas.1410980111. Epub 2014 Aug 28.

Herati RS, et al. Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults. J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29.


Ref:
Mestecky, J. et al. 1971. J. Immunol. 107, 605; Mehl, V.S. and Penn, G.M. 1986. Manual of Clinical Laboratory Immunology (N.R. Rose, ed.), 126