Immunoglobulin M, Fc5mu, Human Plasma

1 mg
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MW: 342,000 Da
Extinction Coefficient: 1.18

Frozen in PBS, pH 7.4

The FC portion of the IgM molecule is important for structural studies and is thought to influence complement fixation and placental permeability.

Storage: <= -20°C

Purity: >=95% by SDS-PAGE. No reaction by IEP to antisera to kappa or lambda.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Anquetil F, et al. IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies. J Immunol. 2015 Apr 15;194(8):3664-74. doi: 10.4049/jimmunol.1402334. Epub 2015 Mar 13.

Hayzer, D. J. et al. 1985. Methods Enzymol. 116, 26; Zikan, J. et al. 1973. Eur. J. Immunol. 3, 415; Plaut, A.G. et al. 1970. Proc. Natl. Acad. Sci. 65, 318.