Secretory Immunoglobulin A, Human Colostrum (SigA)

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10 mg
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MW: 385,000 Da
Extinction Coefficient: 1.26

Lyophilized from 20 mM phosphate, pH 7.4, with 150 mM NaCl.

Secretory Immunoglobulin A (SigA) is the primary immunoglobulin on most mucosal surfaces. SigA is a polypetide complex made up of two IgA monomers, a connecting J chain, and the secretory component. Located on mucosal surfaces, SigA provides protection by preventing invasion of pathogens.

Storage: <= -20°C

Purity: >=95% by SDS-PAGE. No reaction by IEP with antiserum to human Albumin, IgD, IgE, IgG, IgM and Lactoferrin

Prepared from human colostrum shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Bidgood SR, et al. Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8. doi: 10.1073/pnas.1410980111. Epub 2014 Aug 28.