Cathepsin G, Human Neutrophil

100 ug
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MW: 23,500
Extinction Coefficient: 0.664

Salt-free lyophilized solid.

Storage: -20°C

Buy Purified Native Human Cathepsin G (CatG), Human Neutrophil.
Bulk Qty Available.

This enzyme degrades collagen and proteoglycan and can also cause the release of angiotensin II from angiotensin I or angiotensinogen. It has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis.

Ref: Travis, J. et al. 1978. Biochemistry. 17, 5651.

Activity: 2-4 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one umole of Suc-Ala-Ala Pro-Phe-pNA (1 mM) per minute at 25oC in 160 mM Tris-HCl, pH 7.4, with 1.6 M NaCl.

Purity: >=95% by SDS-PAGE

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti- HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Product Citations:
Mittendorf, Elizabeth A., Gheath Alatrash, Na Qiao, Yun Wu, Pariya Sukhumalchandra, Lisa S. St John, Anne V. Philips et al. "Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response." Cancer research 72, no. 13 (2012): 3153-3162.

Baumann, Mathias, Christine TN Pham, and Charaf Benarafa. "SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G." Blood 121, no. 19 (2013): 3900-3907
van den Berg, Carmen W., et al. "Mechanism of Neutrophil Dysfunction: Neutrophil Serine Proteases Cleave and Inactivate the C5a Receptor." The Journal of Immunology 192.4 (2014): 1787-1795.

Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, et al.
Modulation of γδ T cell activation by neutrophil elastase.
Immunology. 2017 Sep 9. doi: 10.1111/imm.12835.

Ksiazek M, et al.
Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop.
J Biol Chem. 2015 Jan 2;290(1):658-70. doi: 10.1074/jbc.M114.601716. Epub 2014 Nov 11.

Thomas MP, et al.
Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins.
J Immunol. 2014 Jun 1;192(11):5390-7. doi: 10.4049/jimmunol.1303296. Epub 2014 Apr 25.