Transferrin (HOLO), Human Plasma, Tissue Culture Grade

100 mg
1 gram
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Note: This product is suitable for cell culture use.

Endotoxin Level: <=0.1EU/mg by LAL testing. Sterile filtered using 0.2 micron filter.

MW: 80,000 Da

Lyophilized from 20 mM Na Phosphate, pH 7.4, and 150 mM NaCl

Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100 ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and prevention of iron loss via the kidneys. Stored in bone marrow as Tf-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypoproteinemias and nephrotic syndrome; increases are found in pregnancy, iron-deficiency anemias, and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important transport factor used in defined culture media.

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Iron Content: >= 1100 ug per gram

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71