Haptoglobin, Human Plasma, Mixed Type

1 mg
5 mg
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MW: Hp 1-1: 86,000; Hp 2-1: 200,000; Hp 2-2: 400,000
Extinction Coefficient: 1.20

Salt-free lyophilized solid.

Storage: <= -20°C

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.

Purity: >=95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Product Citations:
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Sakamoto K, et al.
IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.
Sci Immunol. 2017 Feb;2(8). pii: eaai8371. doi: 10.1126/sciimmunol.aai8371. Epub 2017 Feb 3.

Kozlik P, Goldman R, Sanda M.
Study of structure-dependent chromatographic behavior of glycopeptides using reversed phase nanoLC.
Electrophoresis. 2017 Apr 26. doi: 10.1002/elps.201600547. [Epub ahead of print].

Eshbach ML, et al. Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease.
Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C733-C740. doi: 10.1152/ajpcell.00021.2017. Epub 2017 Mar 29.

Smithies, O et al. 1955. Biochem. J. 61, 629.
Sadrzadeh, S.M.H. et al. 2004. Clin. Chem. 50, 1095.