Apolipoprotein AIV, Human Plasma

PRODUCT NUMBER:

MW: 46,000
Extinction Coefficient: 1.0

Frozen in 1 mM NH4HCO3, pH 8.2

Storage: <= -70°C

Buy Purified Native Human Apolipoprotein A4 (ApoA4), Human Plasma.
Bulk Qty Available.

Apolipoprotein AIV (Apo AIV), is a major component of HDL and chylomicrons, is actively synthesized in the small intestine during fat absorption and incorporated onto the surface of nascent chylomicrons that are then secreted into lymph. When these chylomicrons enter plasma, Apo-AIV dissociates from the surface and is found primarily in the lipoprotein-free fraction.

Apo AIV may play a role in the secretion and catabolism of chylomicrons and VLDL. It is required for efficient activation of lipoprotein lipase by ApoC-II and is a potent activator of LCAT. Apo AIV is an amphipathic protein that can emulsify lipids and has been linked to protective roles against cardiovascular disease and obesity.

Ref: Weinburg, R.B. and Scanu, A. M. J Lipid Res 1983. 24, 52. Dieplinger, H. Menzel, H-J., and Utermann, G. 1992. Lipoprotein Analysis A Practical Approach. (CA Converse and ER Skinner, eds), 43.

Purity: >=85% by SDS-PAGE ; immunoreactive by Western Blot to antisera to human apolipoprotein A4

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.