Haptoglobin, Phenotype 1-1, Human Plasma

1 mg
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Buy Purified Native Human Haptoglobin Phenotype 1-1 direct from manufacturer.

MW: Hp 1-1: 86,000
Extinction Coefficient: 1.20

Salt-free lyophilized solid.

Storage: <= -20°C

Of the three haptoglobin phenotypes, Hp 1-1 is the most effective in binding free hemoglobin and in suppressing the inflammatory responses associated with free hemoglobin. Hp 1-1 protects against vascular complications in diabetes, is associated with sickle cell anemia, and is more common than other phenotypes in cases of cirrhosis.
Individuals who are phenotype 1-1 have the highest concentration of haptoglobin in plasma.

Purity: >=95% by SDS-PAGE, no visible alpha-2 light chain by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Product Citations:
Chen-Roetling J, Regan RF.
Haptoglobin increases the vulnerability of CD163‐expressing neurons to hemoglobin.
J Neurochem. 2016 Nov;139(4):586-595. doi: 10.1111/jnc.13720. Epub 2016 Jul 22.

Xu S, Kaltashov IA.
Evaluation of Gallium as a Tracer of Exogenous Hemoglobin-Haptoglobin Complexes for Targeted Drug Delivery Applications.
J Am Soc Mass Spectrom. 2016 Dec;27(12):2025-2032. Epub 2016 Sep 12.

Fatunmbi O, Abzalimov RR, Savinov SN, Gershenson A, Kaltashov IA.
Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.
Biochemistry. 2016 Mar 29;55(12):1918-28. doi: 10.1021/acs.biochem.5b00807. Epub 2016 Mar 17.

Smithies, O et al. 1955. Biochem. J. 61, 629.
Sadrzadeh, S.M.H. et al. 2004. Clin. Chem. 50, 1095.